Antimicrobial Resistance

The call funded 11 projects to develop innovative solutions to combat antimicrobial resistance.


Appropriate antibiotic use has the power to save lives in the most vulnerable communities, and antimicrobial resistance (AMR) impacts multiple global health priority areas: HIV/AIDS, tuberculosis, maternal and neonatal health, pneumonia, and enteric and diarrheal diseases. It is critical to better understand the prevalence of AMR and its impact on mortality in developing countries so that access to appropriate antibiotics is ensured while inappropriate use of antibiotics is limited. In particular, there is a need to better understand resistance in bacterial infections of newborns and young children – and to this end, understanding what is the prevalence of AMR in the community, how it impacts mortality, and how it impacts health targets. Tackling AMR will require a global, coordinated approach and the linking together of different research communities for new perspectives on the problem.


The program pursued new approaches with the potential to transform public health action on a regional or global scale by identifying and filling gaps in knowledge on the burden of resistance to antibacterial agents.

Specifically, the financed projects proposed innovation in the following areas:

  • Data sources: Pilot tests of new sources of data, particularly those that would bring together different research communities from different disciplines for new perspectives on the problem;
  • Analytical methods: Pilot tests of bioinformatics approaches, including new ways to analyze, combine or connect existing databases;
  • Biomarkers: Pilot tests of new biomarkers or combinations of biomarkers that could lead to a new understanding of the actionable implications of antimicrobial resistance surveillance data;
  • Low-cost technologies and products: Exploratory work in developing new technologies and products, including:
    1. those that specifically target improved infection prevention and control in healthcare settings to reduce reliance on healthcare provider behavior change, and
    2. technologies to remove antibiotics from effluents.

Projects in Antimicrobial Resistance

The use of low-cost immobilized DNA aptamers on cellulose filter to remove antibiotic residues from effluents

Effluents in general and hospital wastewater in particular can have high concentrations of antibiotics. When untreated, such residues have great potential…
Read more

The dynamics of circulation of antibiotic-resistant microorganisms between livestock operations and hospitals

Given the importance of antimicrobials in the livestock industry and the growth of antimicrobial resistance (AMR) in human populations, this project intended…
Read more

OneBR: integrated genomic database for surveillance, diagnosis, management, and treatment of antimicrobial resistance in the human-animal-environment interface

The project aimed to create a database with curated genomic information integrated into diagnosis and antimicrobial resistance results from human, animal,…
Read more

SMART-EP, an artificial intelligence system to strengthen antimicrobial prescription in a children's hospital

The decision on which antimicrobial to prescribe is often difficult for clinicians, whether empirically or using laboratory data. This project proposed…
Read more

Monitoring of antimicrobial resistance in uropathogens from community residents and genetic correlation with isolated resistance determinants from Enterobacterales present in meat consumption

Urinary tract infection (UTI) is the most frequent infection in hospital and community settings, and E. coli is the main uropathogen. E. coli is also becoming…
Read more

Application of metagenomic analysis to the detection of EsβL- and carbapenemase-producing enteric pathogens recovered from different hosts

The project's main objective was to understand the spread of Escherichia coli and Klebsiella pneumoniae, carriers of encoding resistance genes of extended-spectrum…
Read more

Tracking methicillin-resistant Staphylococcus aureus (MRSA) evolution to discover important biomarkers for rapid characterization of unique MRSA clones in hospital bloodstream infections

Methicillin-resistant Staphylococcus aureus (MRSA) is an important agent of hospital infections in which certain prevailing clones occur in epidemic waves…
Read more

Data science on drug-resistant tuberculosis in Brazil

The project´s hypothesis was that individual and social characteristics associated with health services-related factors interact in a nonlinear and complex…
Read more

Application of low-cost and sustainable solar oxidation treatment to prevent microbial resistance in effluents in Brazil

This project used a sustainable solar oxidation system (photo-Fenton) as post-treatment of secondary wastewater from a sewage treatment plant to remove…
Read more

Plasmid curing by an Ethiopian barley: a natural feed/food approach to reduce plasmid mediated antibiotic resistance

Bacterial plasmids are genetic elements that may carry antimicrobial resistance genes, which can be exchanged between bacteria, acting as "messengers"…
Read more

Use of aerobic granular sludge (AGS) to remove antibiotics from hospital wastewater

Hospitals are a leading source of effluents with high concentrations of antibiotics. The final disposal of hospital effluents without prior treatment directly…
Read more

Latest studies published in Antimicrobial Resistance

  1. Pillonetto M, Kalil A, Becker G, Giamberardino AL, Teixeira B, Bergamo R, Madeira H, Dias V, Miorando, Giglio R. (2020). SMART-CDSS An artificial intelligence system for antimicrobial prescription support. Gates Open Res, 4. - 10/2023
  2. Human pandemic K27-ST392 CTX-M-15 extended-spectrum β-lactamase-positive Klebsiella pneumoniae: A one health clone threatening companion animals - 12/2022
  3. Challenges on solar oxidation as post-treatment of municipal wastewater from UASB systems: Treatment efficiency, disinfection and toxicity - 12/2022
  4. Exploring the Bacteriome and Resistome of Humans and Food-Producing Animals in Brazil - 08/2022
  5. World Health Organization critical priority Escherichia coli clone ST648 in magnificent frigatebird (Fregata magnificens) of an uninhabited insular environment - 08/2022
  6. Solar photo-Fenton mediated by alternative oxidants for MWWTP effluent quality improvement: Impact on microbial community, priority pathogens and removal of antibiotic-resistant genes - 08/2022
  7. Different Swine Production Systems Can Shape Slurry Resistome at Mechanism and Class Levels Based on Swine Manure Evaluation - 07/2022
  8. Large Scale Genome-Centric Metagenomic Data from the Gut Microbiome of Food-Producing Animals and Humans - 06/2022
  9. Genomic Analysis of a Highly Virulent NDM-1-Producing Escherichia coli ST162 Infecting a Pygmy Sperm Whale (Kogia breviceps) in South America - 06/2022
  10. Genomic insights of high-risk clones of ESBL-producing Escherichia coli isolated from community infections and commercial meat in southern Brazil - 06/2022
  11. Genomic insights of high-risk clones of ESBL-producing Escherichia coli isolated from community infections and commercial meat in southern Brazil - 06/2022
  12. Phylogenomic analysis of CTX-M-15–producing Enterobacter hormaechei belonging to the high-risk ST78 from animal infection: another successful One Health clone? - 06/2022
  13. Susceptibility to first choice antimicrobial treatment for urinary tract infections to Escherichia coli isolates from women urine samples in community South Brazil - 06/2022

News in Antimicrobial Resistance

No news registered.